Publications Backup


Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology.

Joshi AU, Van Wassenhove LD, Logas KR, Minhas PS, Andreasson KI, Weinberg KI, Chen CH, Mochly-Rosen D. Acta Neuropathol Commun. 2019;7(1):190.

Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop.

Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW II, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O’Brien KD, O’Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L. Circulation. 2019;140(14):1205-1216. Review.

Alcohol consumption and vascular disease: other points to consider.

Chen CH, Ferreira JCB, Mochly-Rosen D, Gross ER. Lancet. 2019;394(10209):1617-1618. No abstract available.

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration.

Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW 2nd, Mochly-Rosen D. Nat Neurosci. 2019;22(10):1635-1648.

ALDH2 and Cardiovascular Disease.

Chen CH, Ferreira JCB, Mochly-Rosen D. Adv Exp Med Biol. 2019;1193:53-67. doi: 10.1007/978-981-13-6260-6_3.PMID: 31368097 Review.

Small-Molecule Activators of Glucose-6-phosphate Dehydrogenase (G6PD) Bridging the Dimer Interface.

Raub AG, Hwang S, Horikoshi N, Cunningham AD, Rahighi S, Wakatsuki S, Mochly-Rosen D. ChemMedChem. 2019;14(14):1321-1324.

Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes.

Ebert A, Joshi AU, Andorf S, Dai Y, Sampathkumar S, Chen H, Li Y, Garg P, Toischer K, Hasenfuss G, Mochly-Rosen D, Wu JC. Circ Res. 2019;125(1):90-103.

Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy.

Haileselassie B, Mukherjee R, Joshi AU, Napier BA, Massis LM, Ostberg NP, Queliconi BB, Monack D, Bernstein D, Mochly-Rosen D. J Mol Cell Cardiol. 2019;130:160-169.

A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.

Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D. Nat Commun. 2019;10(1):329.

Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington’s disease.

Joshi AU, Ebert AE, Haileselassie B, Mochly-Rosen D. J Mol Cell Cardiol. 2019;127:125-133.

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation.

Minhas PS, Liu L, Moon PK, Joshi AU, Dove C, Mhatre S, Contrepois K, Wang Q, Lee BA, Coronado M, Bernstein D, Snyder MP, Migaud M, Majeti R, Mochly-Rosen D, Rabinowitz JD, Andreasson KI. Nat Immunol. 2019;20(1):50-63.

Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries.

Parrish MC, Tan YJ, Grimes KV, Mochly-Rosen D. Annu Rev Pharmacol Toxicol. 2019;59:405-421. Review.


ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.

Sarvi S, Crispin R, Lu Y, Zeng L, Hurley TD, Houston DR, von Kriegsheim A, Chen CH, Mochly-Rosen D, Ranzani M, Mathers ME, Xu X, Xu W, Adams DJ, Carragher NO, Fujita M, Schuchter L, Unciti-Broceta A, Brunton VG, Patton EE. Cell Chem Biol. 2018;25(12):1456-1469.e6.

Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases.

Joshi AU, Mochly-Rosen D. Pharmacol Res. 2018;138:2-15. Review.

Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities.

Kiyuna LA, Albuquerque RPE, Chen CH, Mochly-Rosen D, Ferreira JCB. Free Radic Biol Med. 2018;129:155-168. Review.

Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.

Hwang S, Mruk K, Rahighi S, Raub AG, Chen CH, Dorn LE, Horikoshi N, Wakatsuki S, Chen JK, Mochly-Rosen D. Nat Commun. 2018;9(1):4045.

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo.

Kornfeld OS, Qvit N, Haileselassie B, Shamloo M, Bernardi P, Mochly-Rosen D. Sci Rep. 2018;8(1):14034.

Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.

Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D. (2018) Proc Natl Acad Sci U S A. 2018 May 24. pii:201802184. doi: 10.1073/pnas.1802184115.

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.

Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW 2nd. (2018) Science. 2018 Apr 20;360(6386):336-341. doi: 10.1126/science.aao1785.

Cardioprotection induced by a brief exposure to acetaldehyde:role of aldehyde dehydrogenase 2.

Ueta CB, Campos JC, Albuquerque RPE, Lima VM, Disatnik MH, Sanchez AB, Chen CH, Medeiros MHG, Yang W, Mochly-Rosen D, Ferreira JCB. (2018) Cardiovasc Res. 2018 Mar 20. doi: 10.1093/cvr/cvy070.

Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes.

Deshwal S, Forkink M, Hu CH, Buonincontri G, Antonucci S, Di Sante M, Murphy MP, Paolocci N, Mochly-Rosen D, Krieg T, Di Lisa F, Kaludercic N. (2018) Cell Death Differ. 2018 Feb 19. doi: 10.1038/s41418-018-0071-1.

Transcriptome analysis and prognosis of ALDH isoforms in human cancer.

Chang PM, Chen CH, Yeh CC, Lu HJ, Liu TT, Chen MH, Liu CY, Wu ATH, Yang MH, Tai SK, Mochly-Rosen D, Huang CF. (2018) Sci Rep. 2018 Feb 9;8(1):2713. doi: 10.1038/s41598-018-21123-4.

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.

Joshi AU, Saw NL, Vogel H, Cunningham AD, Shamloo M, Mochly-Rosen D. (2018) EMBO Mol Med. 2018 Jan 15. pii: e8166. doi: 10.15252/emmm.201708166.


Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer’s disease.

Joshi AU, Saw NL, Shamloo M, Mochly-Rosen D. Oncotarget. 2017;9(5):6128-6143.

Human Chitotriosidase Does Not Catabolize Hyaluronan.

Danielson B, Chen CH, Kaber G, Mochly-Rosen D, Grimes K, Stern R, Bollyky PL. (2017) Int J Biol Macromol. 2017 Dec 13;109:629-633. doi: 10.1016/j.ijbiomac.2017.11.181.

Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Alcohol Consumption are Associated With Asymptomatic Cardiac Remodeling and Subclinical Systolic Dysfunction in Large Community-Dwelling Asians. Alcohol Alcohol.

Hung CL, Chang SC, Chang SH, Chi PC, Lai YJ, Wang SW, Wu YJ, Yeh HI, Lin SJ, Chen CH, Mochly-Rosen D, Wang LY. (2017) Alcohol Alcohol. 2017 Aug 31. doi: 10.1093/alcalc/agx049.

Exercise Reestablishes Autophagic Flux and Mitochondrial Quality Control in Heart Failure.

Campos JC, Queliconi BB, Bozi LHM, Bechara LRG, Dourado PM, Andres AM, Jannig PR, Gomes KMS, Zambelli VO, Rocha-Resende C, Guatimosim S, Brum PC, Mochly-Rosen D, Gottlieb RA, Kowaltowski AJ, Ferreira JCB. (2017) Autophagy. 2017 Jun 9. doi: 10.1080/15548627.2017.1325062.

Aldehyde Dehydrogenase 2*2 Knock-In Mice Show Increased Reactive Oxygen Species Production in Response to Cisplatin Treatment.

Kim J, Chen CH, Yang J, Mochly-Rosen D. (2017) J Biomed Sci. 2017 May 22. doi: 10.1186/s12929-017-0338-8.

Targeting Aldehyde Dehydrogenase Activity in Head and Neck Squamous Cell Carcinoma with a Novel Small Molecule Inhibitor.

Kim J, Ho Shin J, Chen CH, Cruz L, Farnebo L, Yang J, Borges P, Kang G, Mochly-Rosen D, Sunwoo JB. (2017) Oncotarget. 2017 Apr 10. doi: 10.18632/oncotarget.17017.

Coupling Between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants.

Cunningham AD, Colavin A, Huang KC, Mochly-Rosen D. (2017) Cell Rep. 2017 Mar 14;18(11):2592-2599. doi: 10.1016/j.celrep.2017.02.048.

Peptides and Peptidomimetics as Regulators of Protein-Protein Interactions.

Cunningham AD, Qvit N, Mochly-Rosen D. (2017) Curr Opin Struct Biol. 2017 Jan 4;44:59-66. doi: 10.1016/

Aldehyde Dehydrogenase 2 Activation and Coevolution of Its εPkc-Mediated Phosphorylation Sites.

Nene A, Chen CH, Disatnik MH, Cruz L, Mochly-Rosen D. (2017) J Biomed Sci. 2017 Jan 5;24(1):3. doi: 10.1186/s12929-016-0312-x.


Genetic Variations of Aldehyde Dehydrogenase 2 and Alcohol Dehydrogenase 1B Are Associated with the Etiology of Atrial Fibrillation in Japanese.

Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironomobe N, Motoda C, Oda N, Chayama K, Chen CH, Gross ER, Mochly-Rosen D, Kihara Y. (2016) J Biomed Sci. 2016 Dec 7;23(1):89

Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics.

Qvit N, Kornfeld OS, Mochly-Rosen D. (2016) Angew Chem Int Ed Engl. 2016 Nov 17. doi: 10.1002/anie.201605429.

Potential Biomarkers to Follow the Progression and Treatment Response of Huntington’s Disease.

Disatnik MH, Joshi AU, Saw NL, Shamloo M, Leavitt BR, Qi X, Mochly-Rosen D. (2016) J Exp Med. 2016 Nov 14;213(12):2655-2669.

Correcting Mitochondrial Fusion by Manipulating Mitofusin Conformations.

Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW 2nd. (2016) Nature. 2016 Oct 24. doi: 10.1038/nature20156.

Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury.

Hurt CM, Lu Y, M Stary C, Piplani H, Small BA, Urban TJ, Qvit N, Gross GJ, Mochly-Rosen D, Gross ER. (2016) J Am Heart Assoc. 2016 Sep 26;5(9). pii: e003774.

Aldehyde Dehydrogenase 2 in Aplastic Anemia, Fanconi Anemia and Hematopoietic Stem Cells.

Van Wassenhove LD, Mochly-Rosen D, Weinberg KI. (2016) Mol Genet Metab. 2016 Sep;119(1-2):28-36. doi: 10.1016/j.ymgme.2016.07.004.

PKC-ALDH22 Pathway Plays a Novel Role in Adipocyte Differentiation.

Yu YH, Liao PR, Guo CJ, Chen CH, Mochly-Rosen D, Chuang LM. (2016) PLoS One. 2016 Aug 30;11(8):e0161993. doi: 10.1371/journal.pone.0161993.

Vcp Recruitment to Mitochondria Causes Mitophagy Impairment and Neurodegeneration in Models of Huntington’s Disease.

Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X. (2016) Nat Commun. 2016 Aug 26;7:12646. doi: 10.1038/ncomms12646.

Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo.

Qvit N, Disatnik MH, Sho E, Mochly-Rosen D, (2016) J Am Chem Soc. 2016 Jun 22;138(24):7626-35. doi: 10.1021/jacs.6b02724.

The Entangled Er-Mitochondrial Axis as a Potential Therapeutic Strategy in Neurodegeneration: A Tangled Duo Unchained.

Joshi AU, Kornfeld OS, Mochly-Rosen D. (2016) Cell Calcium. 2016 May 7. pii: S0143-4160(16)30063-X. doi: 10.1016/j.ceca.2016.04.010.

Gapdh (Glyceraldehyde-3-Phosphate Dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for Gapdh Oligomerization in Cell Death.

Qvit N, Joshi AU, Cunningham AD, Ferreira JC, Mochly-Rosen D. (2016) J Biol Chem. 2016 Apr 27. pii: jbc.M115.711630

Scaffold Proteins Lack and Track as Potential Drug Targets in Kinetoplastid Parasites: Development of Inhibitors.

Qvit N, Schechtman D, Pena DA, Berti DA, Soares CO, Miao Q, Liang LA, Baron LA, Teh-Poot C, Martínez-Vega P, Ramirez-Sierra MJ, Churchill E, Cunningham AD, Malkovskiy AV, Federspiel NA, Gozzo FC, Torrecilhas AC, Manso Alves MJ, Jardim A, Momar N, Dumonteil E, Mochly-Rosen D. (2016) Int J Parasitol Drugs Drug Resist. Feb 12;6(1):74-84.

Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus.

Cunningham AD, Hwang S, Mochly-Rosen D. (2016) Clin Perinatol. 2016 Jun;43(2):341-54. doi: 10.1016/j.clp.2016.01.010.

A Personalized Medicine Approach for Asian Americans with the Aldehyde Dehydrogenase 2*2 Variant.

Gross ER, Zambelli VO, Small BA, Ferreira JC, Chen CH, Mochly-Rosen D. (2015) Annu Rev Pharmacol Toxicol. 2015;55:107-27.

In Vivo Post-Cardiac Arrest Myocardial Dysfunction Is Supported by Camkii-Mediated Calcium Long-Term Potentiation and Mitigated by Alda-1, an Agonist of Aldehyde Dehydrogenase Type 2.

Woods C, Shang C, Taghavi F, Downey P, Zalewski A, Rubio G, Liu J, Homburger J, Grunwald Z, Qi W, Bollensdorff C, Thanaporn P, Ali A, Riemer RK, Kohl P, Mochly-Rosen D, Gerstenfeld E, Large S, Ali Z, Ashley E. (2016) Circulation 2016 Aug 31. pii: CIRCULATIONAHA.116.021618.


Impaired Gapdh-Induced Mitophagy Contributes to the Pathology of Huntington’s Disease.

Hwang S, Disatnik MH, Mochly-Rosen D.(2015) EMBO Mol Med. 2015 Aug 12;7(10):1307-26.

Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases.

Kornfeld OS, Hwang S, Disatnik MH, Chen CH, Qvit N, Mochly-Rosen D. (2015) Circ Res. 2015 May 22;116(11):1783-99.

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.

Chen CH, Cruz LA, Mochly-Rosen D. (2015) Proc Natl Acad Sci. 2015 Mar 10;112(10):3074-9.

New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases.

Disatnik MH, Hwang S, Ferreira JC, Mochly-Rosen D. (2015) J Mol Med. 2015 Mar;93(3):279-87.

Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.

Chiu CC, Yeh TH, Lai SC, Wu-Chou YH, Chen CH, Mochly-Rosen D, Huang YC, Chen YJ, Chen CL, Chang YM, Wang HL, Lu CS. (2015) Exp Neurol. 2015 Jan;263:244-53.


The many hats of protein kinase Cδ: one enzyme with many functions.

Qvit N, Mochly-Rosen D. (2014) Biochem Soc Trans. 2014 Dec;42(6):1529-33.

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.

Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. (2014) Sci Transl Med. 2014 Sep 24;6(255):255ra130.

Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients

Zambelli VO, Gross ER, Chen CH, Gutierrez VP, Cury Y, Mochly-Rosen D. (2014) Sci Transl Med. 2014 Sep 5;9(9):1603-10.

Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.

Gomes KM, Campos JC, Bechara LR, Queliconi B, Lima VM, Disatnik MH, Magno P, Chen CH, Brum PC, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC. (2014) Cardiovasc Res. 2014 Sep 1;103(4):498-508.

Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.

Zambelli VO, Gross ER, Chen CH, Gutierrez VP, Cury Y, Mochly-Rosen D. (2014) Sci Transl Med. 2014 Aug 27;6(251):251ra118.

The challenge in translating basic research discoveries to treatment of Huntington disease.

Mochly-Rosen D, Disatnik MH, Qi X (2014) Rare Dis. 2014 Mar 31;2:e28637.

Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats.

Zambelli VO, Fernandes AC, Gutierrez VP, Ferreira JC, Parada CA, Mochly-Rosen D, Cury Y. (2014) PLoS One. 2014 Mar 4;9(3):e90576.

Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: Benefits of Alda-1.

Gomes KM, Bechara LR, Lima VM, Ribeiro MA, Campos JC, Dourado PM, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC (2014) Int J Cardiol. 2015 Jan 20;179:129-38.


Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction.

Disatnik MH, Ferreira JC, Campos JC, Gomes KS, Dourado PM, Qi X, Mochly-Rosen D. (2013) J Am Heart Assoc. 2013 Oct 8;2(5):e000461

Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C.

Gross ER, Hsu AK, Urban TJ, Mochly-Rosen D, Gross GJ. (2013) Basic Res Cardiol. 108(5):381.

A Novel Aldehyde Dehydrogenase-3 Activator (Alda-89) Protects Submandibular Gland Function from Irradiation without Accelerating Tumor Growth.

Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT. (2013) Clin Cancer Res. 19(16):4455-64

Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Phosphorylation by PKCδ Inhibits Mitochondria Elimination by Lysosomal-like Structures following Ischemia and Reoxygenation-induced Injury.

Yogalingam G, Hwang S, Ferreira JC, Mochly-Rosen D. (2013) J Biol Chem. 288(26):18947-60

In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate.

Josan S, Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D. (2013) NMR Biomed.

Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice.

Sun X, Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG. (2013) J Neurosci Res. 2013 Jun;91(6):799-807.


Protein kinase C, an elusive therapeutic target?

Mochly-Rosen D, Das K, Grimes KV. (2012) Nat. Rev. Drug Discov. 11(12):937-57

Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice.

Ning S, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D. (2012) Radiat. Res. 178(1):69-74

Identification of εPKC targets during cardiac ischemic injury.

Budas G, Costa HM, Ferreira JC, Teixeira da Silva Ferreira A, Perales J, Krieger JE, Mochly-Rosen D, Schechtman D. (2012) Circ. J. 76(6):1476-85

Nitroglycerin use in myocardial infarction patients.

Ferreira JC, Mochly-Rosen D. (2012) Circ. J. 76(1):15-21

Regulation of cardiac excitability by protein kinase C isozymes.

Ferreira JC, Mochly-Rosen D, Boutjdir M. (2012) Front Biosci (Schol Ed) 4:532-46

Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3.

Ferreira JC, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D. (2012) PLoS ONE. 7(3):e33175


Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy.

Ferreira JC, Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D. (2011) J. Mol. Cell. Cardiol. 51(6):980-7

A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo.

Banh A, Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, Koong AC, Le QT. (2011) Clin. Cancer Res. 17(23):7265-72

β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways.

Fajardo G, Zhao M, Berry G, Wong LJ, Mochly-Rosen D, Bernstein D. (2011) J. Mol. Cell. Cardiol. 51(5):781-9

βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure.

Ferreira JC, Brum PC, Mochly-Rosen D. (2011) J. Mol. Cell. Cardiol. 51(4):479-84

PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses.

Palaniyandi SS, Ferreira JC, Brum PC, Mochly-Rosen D. (2011) J. Cell. Mol. Med. 15(8):1769-77

Therapeutic potential for protein kinase C inhibitor in vascular restenosis.

Ding RQ, Tsao J, Chai H, Mochly-Rosen D, Zhou W. (2011) J. Cardiovasc. Pharmacol. Ther. 16(2):160-7

PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells.

Kim J, Koyanagi T, Mochly-Rosen D. (2011) Prostate. 71(9):946-54

Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells.

Ding Q, Chai H, Mahmood N, Tsao J, Mochly-Rosen D, Zhou W. (2011) J. Vasc. Surg. 53(4):1044-51

Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model.

Kim J, Thorne SH, Sun L, Huang B, Mochly-Rosen D. (2011) Oncogene 30(3):323-33

Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo.

Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D. (2011) Mol. Biol. Cell 22(2):256-65


Mitochondrial aldehyde dehydrogenase and cardiac diseases.

Chen CH, Sun L, Mochly-Rosen D. (2010) Cardiovasc. Res. 88(1):51-7

Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury.

Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D. (2010) Cardiovasc. Res. 88(1):83-92

Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.

Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S. (2010) Circulation 122(11 Suppl):S170-8

Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells.

Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. (2010) Circulation 122(8):771-81

Regulation of mitochondrial processes: a target for heart failure.

Palaniyandi SS, Qi X, Yogalingam G, Ferreira JC, Mochly-Rosen D. (2010) Drug Discov Today Dis Mech 7(2):e95-e102

Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure.

Qvit N, Mochly-Rosen D. (2010) Drug Discov Today Dis Mech 7(2):e87-e93

Non-volume-loaded heart provides a more relevant heterotopic transplantation model.

Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S. (2010) Transpl. Immunol. 23(1-2):65-70

Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.

Monti M, Donnini S, Giachetti A, Mochly-Rosen D, Ziche M. (2010) J. Mol. Cell. Cardiol. 48(4):746-56

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.

Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. (2010) Nat. Struct. Mol. Biol. 17(2):159-64

Ischaemic preconditioning improves proteasomal activity and increases the degradation of δPKC during reperfusion.

Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. (2010) Cardiovasc. Res. 85(2):385-94

Focus on: The cardiovascular system: what did we learn from the French (Paradox)?

Mochly-Rosen D, Zakhari S. (2010) Alcohol Res Health. 2010;33(1-2):76-86.


Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?

Budas GR, Disatnik MH, Mochly-Rosen D. (2009) Trends Cardiovasc. Med. 19(5):158-64

Protein kinase C in heart failure: a therapeutic target?

Palaniyandi SS, Sun L, Ferreira JC, Mochly-Rosen D. (2009) Cardiovasc. Res. 82(2):229-39

Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model.

Kaneda H, Ikeno F, Inagaki K, Mochly-Rosen D. (2009) Int. J. Cardiol. 133(2):256-9

Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2.

Churchill EN, Disatnik MH, Mochly-Rosen D. (2009) J. Mol. Cell. Cardiol. 46(2):278-84

Activating δPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats.

Castañeda D, Zhao H, Mochly-Rosen D, Steinberg GK. (2009) Brain Res. 1251:256-61

Rationally designed peptide regulators of protein kinase C.

Churchill EN, Qvit N, Mochly-Rosen D. (2009) Trends Endocrinol. Metab. 20(1):25-33


Ethanol for cardiac ischemia: the role of protein kinase c.

Churchill EN, Disatnik MH, Budas GR, Mochly-Rosen D. (2008) Ther Adv Cardiovasc Dis 2(6):469-83

Mast cells and εPKC: a role in cardiac remodeling in hypertension-induced heart failure.

Palaniyandi SS, Inagaki K, Mochly-Rosen D. (2008) J. Mol. Cell. Cardiol. 45(6):779-86

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.

Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. (2008) Science 321(5895):1493-5

Centrosomal PKCβII and pericentrin are critical for human prostate cancer growth and angiogenesis.

Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D. (2008) Cancer Res. 68(16):6831-9

epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury.

Bright R, Sun GH, Yenari MA, Steinberg GK, Mochly-Rosen D. (2008) Neurosci. Lett. 441(1):120-4

Alteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats.

Koyanagi T, Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D. (2008) Am. J. Physiol. Heart Circ. Physiol. 295(1):H220-6

Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure.

Inagaki K, Koyanagi T, Berry NC, Sun L, Mochly-Rosen D. (2008) Hypertension 51(6):1565-9

Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways.

Yao L, Fan P, Jiang Z, Gordon A, Mochly-Rosen D, Diamond I. (2008) Mol. Pharmacol. 73(4):1105-12

The PKCdelta -Abl complex communicates ER stress to the mitochondria – an essential step in subsequent apoptosis.

Qi X, Mochly-Rosen D. (2008) J. Cell. Sci. 121(Pt 6):804-13

Islet cell survival during isolation improved through protein kinase C epsilon activation.

Kvezereli M, Vallentin A, Mochly-Rosen D, Busque S, Fontaine MJ. (2008) Transplant. Proc. 40(2):375-8

Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.

Bates E, Bode C, Costa M, Gibson CM, Granger C, Green C, Grimes K, Harrington R, Huber K, Kleiman N, Mochly-Rosen D, Roe M, Sadowski Z, Solomon S, Widimsky P. (2008) Circulation 117(7):886-96

Sustained pharmacological inhibition of δPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats.

Qi X, Inagaki K, Sobel RA, Mochly-Rosen D. (2008) J. Clin. Invest. 118(1):173-82

PKC isozymes in chronic cardiac disease: possible therapeutic targets?

Churchill E, Budas G, Vallentin A, Koyanagi T, Mochly-Rosen D. (2008) Annu. Rev. Pharmacol. Toxicol. 48:569-99


Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 – 2007).

Newton AC, Mochly-Rosen D. (2007) IUBMB Life 59(12):741-3

Mitochondrial protein kinase Cepsilon (PKCepsilon): emerging role in cardiac protection from ischaemic damage.

Budas GR, Mochly-Rosen D. (2007) Biochem. Soc. Trans. 35(Pt 5):1052-4

Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic.

Budas GR, Koyanagi T, Churchill EN, Mochly-Rosen D. (2007) Biochem. Soc. Trans. 35(Pt 5):1021-6

The roles of PKC delta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury.

Churchill EN, Mochly-Rosen D. (2007) Biochem. Soc. Trans. 35(Pt 5):1040-2

Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model.

Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D. (2007) J. Mol. Cell. Cardiol. 43(4):517-22

Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia.

Shimohata T, Zhao H, Sung JH, Sun G, Mochly-Rosen D, Steinberg GK. (2007) J. Cereb. Blood Flow Metab. 27(8):1463-75

Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury.

Budas GR, Churchill EN, Mochly-Rosen D. (2007) Pharmacol. Res. 55(6):523-36

Happy birthday protein kinase C: past, present and future of a superfamily.

Battaini F, Mochly-Rosen D. (2007) Pharmacol. Res. 55(6):461-6

Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function.

Kheifets V, Mochly-Rosen D. (2007) Pharmacol. Res. 55(6):467-76

DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo.

Bright R, Steinberg GK, Mochly-Rosen D. (2007) Brain Res. 1144:146-55

Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide.

Liron T, Chen LE, Khaner H, Vallentin A, Mochly-Rosen D. (2007) J. Mol. Cell. Cardiol. 42(4):835-41

Impaired perfusion after myocardial infarction is due to reperfusion-induced δPKC-mediated myocardial damage.

Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D. (2007) Cardiovasc. Res. 73(4):699-709

Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase.

Siwko S, Mochly-Rosen D. (2007) Int. J. Biochem. Cell Biol. 39(5):978-87


Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function.

Kheifets V, Bright R, Inagaki K, Schechtman D, Mochly-Rosen D. (2006) J. Biol. Chem. 281(32):23218-26.

Epsilon protein kinase C as a potential therapeutic target for the ischemic heart.

Inagaki K, Churchill E, Mochly-Rosen D. (2006) Cardiovasc. Res. 70(2):222-30


The role of protein kinase C in cerebral ischemic and reperfusion injury.

Bright R, Mochly-Rosen D. (2005) Stroke 36(12):2781-90

PKC-{epsilon}-dependent survival signals in diabetic hearts.

Malhotra A, Begley R, Kang BP, Rana I, Liu J, Yang G, Mochly-Rosen D, Meggs LG. (2005) Am. J. Physiol. Heart Circ. Physiol. 289(4):H1343-50

RSA 2004: combined basic research satellite symposium – session three: alcohol and mitochondrial metabolism: at the crossroads of life and death.

Szabo G, Hoek JB, Darley-Usmar V, Hajnoczky G, Knudsen T, Mochly-Rosen D, Zakhari S. (2005) Alcohol. Clin. Exp. Res. 29(9):1749-52

Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes.

Shumilla JA, Liron T, Mochly-Rosen D, Kendig JJ, Sweitzer SM. (2005) J Pain 6(8):535-49

DeltaPKC-mediated activation of epsilonPKC in ethanol-induced cardiac protection from ischemia.

Inagaki K, Mochly-Rosen D. (2005) J. Mol. Cell. Cardiol. 39(2):203-11

Reperfusion-induced translocation of δPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation.

Churchill EN, Murriel CL, Chen CH, Mochly-Rosen D, Szweda LI. (2005) Circ. Res. 97(1):78-85

Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation.

Raval AP, Dave KR, Prado R, Katz LM, Busto R, Sick TJ, Ginsberg MD, Mochly-Rosen D, Pérez-Pinzón MA. (2005) J. Cereb. Blood Flow Metab. 25(6):730-41

Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.

Tanaka M, Gunawan F, Terry RD, Inagaki K, Caffarelli AD, Hoyt G, Tsao PS, Mochly-Rosen D, Robbins RC. (2005) J. Thorac. Cardiovasc. Surg. 129(5):1160-7

Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons.

Li HF, Mochly-Rosen D, Kendig JJ. (2005) Br. J. Pharmacol. 144(3):301-7

Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide.

Inagaki K, Begley R, Ikeno F, Mochly-Rosen D. (2005) Circulation 111(1):44-50


Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria.

Murriel CL, Churchill E, Inagaki K, Szweda LI, Mochly-Rosen D. (2004) J. Biol. Chem. 279(46):47985-91

Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.

Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC. (2004) Circulation. 2004 Sep 14;110(11 Suppl 1):II194-9.

Protein kinase C delta mediates cerebral reperfusion injury in vivo.

Bright R, Raval AP, Dembner JM, Pérez-Pinzón MA, Steinberg GK, Yenari MA, Mochly-Rosen D. (2004) J. Neurosci. 24(31):6880-8

RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling.

Miller LD, Lee KC, Mochly-Rosen D, Cartwright CA. (2004) Oncogene 23(33):5682-6

Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma.

Sweitzer SM, Wong SM, Tjolsen A, Allen CP, Mochly-Rosen D, Kendig JJ. (2004) Pain 110(1-2):281-9

Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury.

Wang J, Bright R, Mochly-Rosen D, Giffard RG. (2004) Neuropharmacology 47(1):136-45

Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice.

Lange-Asschenfeldt C, Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA. (2004) J. Cereb. Blood Flow Metab. 24(6):636-45

Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats.

Sweitzer SM, Wong SM, Peters MC, Mochly-Rosen D, Yeomans DC, Kendig JJ. (2004) J. Pharmacol. Exp. Ther. 309(2):616-25

State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation.

Souroujon MC, Yao L, Chen H, Endemann G, Khaner H, Geeraert V, Schechtman D, Gordon AS, Diamond I, Mochly-Rosen D. (2004) J. Biol. Chem. 279(17):17617-24

Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon.

Gray MO, Zhou HZ, Schafhalter-Zoppoth I, Zhu P, Mochly-Rosen D, Messing RO. (2004) J. Biol. Chem. 279(5):3596-604

A critical intramolecular interaction for protein kinase Cε translocation.

Schechtman D, Craske ML, Kheifets V, Meyer T, Schechtman J, Mochly-Rosen D. (2004) J. Biol. Chem. 279(16):15831-40

Biodistribution of intracellularly acting peptides conjugated reversibly to Tat.

Begley R, Liron T, Baryza J, Mochly-Rosen D. (2004) Biochem. Biophys. Res. Commun. 318(4):949-54


Opposing roles of delta and εPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery.

Murriel CL, Mochly-Rosen D. (2003) Arch. Biochem. Biophys. 420(2):246-54

Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo.

Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D. (2003) Circulation 108(19):2304-7

Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator.

Inagaki K, Hahn HS, Dorn GW, Mochly-Rosen D. (2003) Circulation 108(7):869-75

Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors.

Braun MU, Mochly-Rosen D. (2003) J. Mol. Cell. Cardiol. 35(8):895-903

PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current.

Xiao GQ, Mochly-Rosen D, Boutjdir M. (2003) Biochem. Biophys. Res. Commun. 306(4):1019-25

Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta.

Koponen S, Kurkinen K, Akerman KE, Mochly-Rosen D, Chan PH, Koistinaho J. (2003) J. Neurochem. 86(2):442-50

Cytotoxicity of pEGFP vector is due to residues encoded by multiple cloning site.

Endemann G, Schechtman D, Mochly-Rosen D. (2003) Anal. Biochem. 313(2):345-7

Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice.

Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA. (2003) J. Neurosci. 23(2):384-91

Methods for detecting binding proteins: an introduction.

Endemann G, Mochly-Rosen D. (2003) Methods Mol. Biol. 233:307-25

Glutathione S-transferase pull-down assay.

Schechtman D, Mochly-Rosen D, Ron D. (2003) Methods Mol. Biol. 233:345-50

Overlay method for detecting protein-protein interactions.

Schechtman D, Murriel C, Bright R, Mochly-Rosen D. (2003) Methods Mol. Biol. 233:351-7


The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.

Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Mochly-Rosen D, Hamm HE. (2002) J. Biol. Chem. 277(51):49888-95

Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta.

Inagaki K, Iwanaga Y, Sarai N, Onozawa Y, Takenaka H, Mochly-Rosen D, Kihara Y. (2002) J. Mol. Cell. Cardiol. 34(10):1377-85

Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts.

Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO. (2002) Am. J. Physiol. Heart Circ. Physiol. 282(6):H1970-7

Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway.

Disatnik MH, Boutet SC, Lee CH, Mochly-Rosen D, Rando TA. (2002) J. Cell. Sci. 115(Pt 10):2151-63

Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.

Knauf JA, Ward LS, Nikiforov YE, Nikiforova M, Puxeddu E, Medvedovic M, Liron T, Mochly-Rosen D, Fagin JA. (2002) J. Clin. Endocrinol. Metab. 87(5):2150-9

Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta.

Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI. (2002) Mol. Biol. Cell. 13(4):1381-9

Molecular dynamics characterization of the C2 domain of protein kinase Cβ.

Banci L, Cavallaro G, Kheifets V, Mochly-Rosen D. (2002) J. Biol. Chem. 277(15):12988-97

Intracellular transport mechanisms of signal transducers.

Dorn GW, Mochly-Rosen D. (2002) Annu. Rev. Physiol. 64:407-29

Moderate alcohol exposure protects cardiac myocytes from ischemia-reperfusion injury.

Gray MO, Mochly-Rosen D. In Alcohol and Heart Disease. Watson RR, Myers AK (eds). Taylor and Francis, New York, pp 104-113, 2002.


Molecular transporters for peptides: delivery of a cardioprotective εPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7).

Chen L, Wright LR, Chen CH, Oliver SF, Wender PA, Mochly-Rosen D. (2001) Chem. Biol. 8(12):1123-9

Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Na(+) channels.

Xiao GQ, Qu Y, Sun ZQ, Mochly-Rosen D, Boutjdir M. (2001) Am. J. Physiol., Cell Physiol. 281(5):C1477-86

Adaptor proteins in protein kinase C-mediated signal transduction.

Schechtman D, Mochly-Rosen D. (2001) Oncogene 20(44):6339-47

Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.

Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavallaro G, Banci L, Guo Y, Bolli R, Dorn GW, Mochly-Rosen D. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(20):11114-9

Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.

Stebbins EG, Mochly-Rosen D. (2001) J. Biol. Chem. 276(32):29644-50

Localization, anchoring, and functions of protein kinase C isozymes in the heart.

Mackay K, Mochly-Rosen D. (2001) J. Mol. Cell. Cardiol. 33(7):1301-7

Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C.

Mackay K, Mochly-Rosen D. (2001) Cardiovasc. Res. 50(1):65-74

Opposing effects of delta and xi PKC in ethanol-induced cardioprotection.

Chen C, Mochly-Rosen D. (2001) J. Mol. Cell. Cardiol. 33(3):581-5

Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis.

Mochly-Rosen D, Fagin JA, Knauf JA, Nikiforov Y, Liron T, Schechtman D. (2001) Adv. Enzyme Regul. 41:87-97

Isozyme-specific inhibitors and activators of protein kinase C.

Schechtman D, Mochly-Rosen D. (2002) Meth. Enzymol. 345:470-89

Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Ca(2+) channels.

Hu K, Mochly-Rosen D, Boutjdir M. (2000) Am. J. Physiol. Heart Circ. Physiol. 279(6):H2658-64

Protein kinase C isozymes and the regulation of diverse cell responses.

Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. (2000) Am. J. Physiol. Lung Cell Mol. Physiol. 279(3):L429-38


Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia.

Mackay K, Mochly-Rosen D. (2000) J. Mol. Cell. Cardiol. 32(8):1585-8

Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.

Aley KO, Messing RO, Mochly-Rosen D, Levine JD. (2000) J. Neurosci. 20(12):4680-5

Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation.

Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, Dorn GW. (2000) Circ. Res. 86(11):1173-9

Pharmacological regulation of network kinetics by protein kinase C localization.

Mochly-Rosen D, Kauvar LM. (2000) Semin. Immunol. 12(1):55-61


Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes.

Liu GS, Cohen MV, Mochly-Rosen D, Downey JM. (1999) J. Mol. Cell. Cardiol. 31(10):1937-48

Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation.

Dorn GW, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN, Mochly-Rosen D. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(22):12798-803

Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C.

Chen CH, Gray MO, Mochly-Rosen D. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(22):12784-9

RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro.

Rodriguez MM, Ron D, Touhara K, Chen CH, Mochly-Rosen D. (1999) Biochemistry 38(42):13787-94

Involvement of protein kinase Cε (PKCε) in thyroid cell death. A truncated chimeric PKCε cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.

Knauf JA, Elisei R, Mochly-Rosen D, Liron T, Chen XN, Gonsky R, Korenberg JR, Fagin JA. (1999) J. Biol. Chem. 274(33):23414-25

Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C.

Rodriguez MM, Chen CH, Smith BL, Mochly-Rosen D. (1999) FEBS Lett. 454(3):240-6

Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation.

Csukai M, Mochly-Rosen D. (1999) Pharmacol. Res. 39(4):253-9

An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia.

Mackay K, Mochly-Rosen D. (1999) J. Biol. Chem. 274(10):6272-9


Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis.

Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC. (1998) J. Biol. Chem. 273(46):30306-15

Peptide modulators of protein-protein interactions in intracellular signaling.

Souroujon MC, Mochly-Rosen D. (1998) Nat. Biotechnol. 16(10):919-24

Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption.

Miyamae M, Rodriguez MM, Camacho SA, Diamond I, Mochly-Rosen D, Figueredo VM. (1998) Proc. Natl. Acad. Sci. U.S.A. 95(14):8262-7

Anchoring proteins for protein kinase C: a means for isozyme selectivity.

Mochly-Rosen D, Gordon AS. (1998) FASEB J. 12(1):35-42

Modulating protein kinase C signal transduction.

Mochly-Rosen D, Kauvar LM. (1998) Adv. Pharmacol. 44:91-145

Molecular genetic approaches. II. Expression-interaction cloning.

Csukai M, Mochly-Rosen D. (1998) Methods Mol. Biol. 88:133-9


A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death.

Gray MO, Karliner JS, Mochly-Rosen D. (1997) J. Biol. Chem. 272(49):30945-51

The coatomer protein beta’-COP, a selective binding protein (RACK) for protein kinase Cε.

Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D. (1997) J. Biol. Chem. 272(46):29200-6

An inhibitory fragment derived from protein kinase Cε prevents enhancement of nerve growth factor responses by ethanol and phorbol esters.

Hundle B, McMahon T, Dadgar J, Chen CH, Mochly-Rosen D, Messing RO. (1997) J. Biol. Chem. 272(23):15028-35

C2 region-derived peptides of beta-protein kinase C regulate cardiac Ca2+ channels.

Zhang ZH, Johnson JA, Chen L, El-Sherif N, Mochly-Rosen D, Boutjdir M. (1997) Circ. Res. 80(5):720-9

Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells.

Yedovitzky M, Mochly-Rosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E, Nesher R. (1997) J. Biol. Chem. 272(3):1417-20

Expression-interaction cloning.

Csukai M, Mochly-Rosen D. In Methods in Molecular Biology: Protein Targeting Protocols. R.A. Clegg (ed). Humana Press, Inc., Totowa, NJ, pp 133-139, 1997.


An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research.

Johnson JA, Gray MO, Karliner JS, Chen CH, Mochly-Rosen D. (1996) Circ. Res. 79(6):1086-99

A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function.

Johnson JA, Gray MO, Chen CH, Mochly-Rosen D. (1996) J. Biol. Chem. 271(40):24962-6

Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells.

Zhou LY, Disatnik M, Herron GS, Mochly-Rosen D, Karasek MA. (1996) J. Invest. Dermatol. 107(2):248-52

The HIV nef protein associates with protein kinase C theta.

Smith BL, Krushelnycky BW, Mochly-Rosen D, Berg P. (1996) J. Biol. Chem. 271(28):16753-7

Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis.

Cardone MH, Smith BL, Mennitt PA, Mochly-Rosen D, Silver RB, Mostov KE. (1996) J. Cell Biol. 133(5):997-1005

Ethanol and signal transduction in the myocardium: implications for the detrimental and beneficial effects.

Figueredo VM, Mochly-Rosen D. In Alcohol and the Cardiovascular System. Zakhari S and Wassef M (eds). CSR, Inc., Washington, DC pp 263-277, 1996.


Stimulus-dependent subcellular localization of activated protein kinase C; a study with acidic fibroblast growth factor and transforming growth factor-beta 1 in cardiac myocytes.

Disatnik MH, Jones SN, Mochly-Rosen D. (1995) J. Mol. Cell. Cardiol. 27(11):2473-81

Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes.

Johnson JA, Adak S, Mochly-Rosen D. (1995) Life Sci. 57(11):1027-38

The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.

Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF. (1995) Proc. Natl. Acad. Sci. U.S.A. 92(17):7824-8

Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: a role in beta protein kinase C mediated signal transduction.

Mochly-Rosen D, Smith BL, Chen CH, Disatnik MH, Ron D. (1995) Biochem. Soc. Trans. 23(3):596-600

Localization of protein kinases by anchoring proteins: a theme in signal transduction.

Mochly-Rosen D. (1995) Science 268(5208):247-51

Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme.

Johnson JA, Mochly-Rosen D. (1995) Circ. Res. 76(4):654-63

An autoregulatory region in protein kinase C: the pseudoanchoring site.

Ron D, Mochly-Rosen D. (1995) Proc. Natl. Acad. Sci. U.S.A. 92(2):492-6


Agonists and antagonists of protein kinase C function, derived from its binding proteins.

Ron D, Mochly-Rosen D. (1994) J. Biol. Chem. 269(34):21395-8

Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells.

Disatnik MH, Winnier AR, Mochly-Rosen D, Arteaga CL. (1994) Cell Growth Differ. 5(8):873-80

Developmental expression of protein kinase C subspecies in rat brain-pituitary axis.

Garcia-Navarro S, Marantz Y, Eyal R, Kalina M, Disatnik MH, Mochly-Rosen D, Ben-Menahem D, Reiss N, Naor Z. (1994) Mol. Cell. Endocrinol. 103(1-2):133-8

Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells.

Cardone MH, Smith BL, Song W, Mochly-Rosen D, Mostov KE. (1994) J. Cell Biol. 124(5):717-27

Localization of protein kinase C isozymes in cardiac myocytes.

Disatnik MH, Buraggi G, Mochly-Rosen D. (1994) Exp. Cell Res. 210(2):287-97

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(3):839-43

Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.

Disatnik MH, Hernandez-Sotomayor SM, Jones G, Carpenter G, Mochly-Rosen D. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(2):559-63


Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme.

Smith BL, Mochly-Rosen D. (1992) Biochem. Biophys. Res. Commun. 188(3):1235-40

Nicotinic acetylcholine receptor desensitization is regulated by activation-induced extracellular adenosine accumulation.

Pitchford S, Day JW, Gordon A, Mochly-Rosen D. (1992) J. Neurosci. 12(11):4540-4

p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C.

Mochly-Rosen D, Miller KG, Scheller RH, Khaner H, Lopez J, Smith BL. (1992) Biochemistry 31(35):8120-4

Alcoholism: a possible G protein disorder.

Gordon AS, MOCHLY-ROSEN D, Diamond I. In G proteins, signal transduction and disease. Milligan G, Wakelam MJO (eds). Academic Press, Ltd., London, pp 191-216, 1992.


G protein and alcoholism.

Gordon AS, Mochly-Rosen D, Diamond I. In Dysfunction of G-protein linked cascades in cellular pathology. Milligan G and Wakelam MJO (eds). Academic Press, (1991).

The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism.

Diamond I, Nagy L, Mochly-Rosen D, Gordon A. (1991) Ann. N. Y. Acad. Sci. 625:473-87

Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme.

Mochly-Rosen D, Khaner H, Lopez J, Smith BL. (1991) J. Biol. Chem. 266(23):14866-8

Identification of intracellular receptor proteins for activated protein kinase C.

Mochly-Rosen D, Khaner H, Lopez J. (1991) Proc. Natl. Acad. Sci. U.S.A. 88(9):3997-4000

The identification and purification of a mammalian-like protein kinase C in the yeast Saccharomyces cerevisiae.

Simon AJ, Milner Y, Saville SP, Dvir A, Mochly-Rosen D, Orr E. (1991) Proc. Biol. Sci. 243(1307):165-71


GTP-binding proteins are restricted to signal transduction sites.

Mochly-Rosen D, Gordon AS. (1990) Biochem. Biophys. Res. Commun. 173(1):388-95

Reduced adenosine receptor activation in alcoholism: implications for alcohol withdrawal seizures.

Diamond I, Mochly-Rosen D, Gordon AS. In Alcohol and seizures: basic mechanisms and clinical concepts. Porter R, Mattson R, Kramer J and Diamond I (eds). FA Davis, Philadelphia, pp 79-86, (1990).

A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC. (1990) Cell Regul. 1(9):693-706

Chronic ethanol-induced heterologous desensitization is mediated by changes in adenosine transport.

Gordon AS, Nagy L, Mochly-Rosen D, Diamond I. (1990) Biochem. Soc. Symp. 56:117-36


↑ Back To Top